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Juiwanna Kushner Selected Research

glycinamide ribonucleotide

1/2018Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis.
10/2011Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase.

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Juiwanna Kushner Research Topics

Disease

17Neoplasms (Cancer)
10/2019 - 02/2002
5Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2021 - 11/2019
3Leukemia
08/2020 - 02/2002
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
01/2020
1Ovarian Epithelial Carcinoma
01/2017
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2016
1Malignant Mesothelioma
04/2013
1Adenocarcinoma
07/2003

Drug/Important Bio-Agent (IBA)

10Proton-Coupled Folate TransporterIBA
10/2018 - 10/2011
9pyrimidineIBA
10/2018 - 12/2011
8Folic Acid AntagonistsIBA
01/2018 - 12/2011
7Folic Acid (Vitamin M)FDA LinkGeneric
10/2018 - 10/2011
4venetoclaxIBA
01/2021 - 11/2019
4Reduced Folate Carrier ProteinIBA
01/2017 - 02/2010
3purineIBA
10/2018 - 01/2016
3NucleotidesIBA
10/2018 - 01/2016
3XK 469 (XK469)IBA
06/2005 - 02/2002
2CUDC-907IBA
01/2021 - 11/2019
2glycinamide ribonucleotideIBA
01/2018 - 10/2011
2Hydroxymethyl and Formyl TransferasesIBA
01/2018 - 10/2011
2EstersIBA
10/2011 - 02/2010
1fms-Like Tyrosine Kinase 3IBA
01/2021
1IACS-010759IBA
08/2020
1voruciclibIBA
01/2020
1gilteritinibIBA
11/2019
1midostaurinIBA
11/2019
1Histone Deacetylases (Histone Deacetylase)IBA
11/2019
1Glycine (Aminoacetic Acid)FDA LinkGeneric
10/2019
1Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)IBA
10/2019
1NAD (NADH)IBA
10/2019
1EnzymesIBA
10/2019
1Adenosine Triphosphate (ATP)IBA
10/2019
1FluorineIBA
10/2018
1Cisplatin (Platino)FDA LinkGeneric
01/2017
1Pemetrexed (MTA)FDA Link
04/2016
1Protons (Proton)IBA
04/2013
1Proteins (Proteins, Gene)FDA Link
10/2012
1Pharmaceutical PreparationsIBA
10/2012
1Glutamic Acid (Glutamate)FDA Link
10/2011
1ThiophenesIBA
02/2010
1AcidsIBA
02/2010
1propionic acid (potassium propionate)IBA
06/2005
1cryptophycinIBA
06/2005
1quinolineIBA
02/2005
1QuinoxalinesIBA
02/2005
1cremophorIBA
07/2003
1Epoxy Compounds (Epoxides)IBA
07/2003
1ProdrugsIBA
07/2003
1cryptophycin 55IBA
07/2003
1cryptophycin 52 (cryptophycin-52)IBA
07/2003
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
02/2003
1AgarIBA
02/2003
1Cytarabine (Cytosar-U)FDA LinkGeneric
02/2002
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
02/2002
1GemcitabineFDA Link
02/2002
1Carmustine (FIVB)FDA Link
02/2002
1Etoposide (VP 16)FDA LinkGeneric
02/2002
1Dacarbazine (DIC)FDA LinkGeneric
02/2002

Therapy/Procedure

3Therapeutics
01/2021 - 04/2016